Genetics Northern California

California Prenatal Screening Program

The California Prenatal Screening Program offers optional testing to all pregnant women in California. The test looks for certain conditions in a developing baby. You can decide if you want to learn about the chance for the following conditions: 

The screening test has three different forms, but all three forms look for the same conditions. The test includes one or two blood tests and may also include an ultrasound. The name of the test is based on what information is used for the result.  
Click on the names below to learn more about the different forms of California Prenatal Screening tests: 
SEQUENTIAL INTEGRATED SCREENING
  • Two blood tests:  One in the first trimester (10 to 13 weeks) and one in the second trimester (15 to 20 weeks)
  • Nuchal translucency (NT) ultrasound: Done between 11 weeks 2 days and 14 weeks 2 days.

Sequential integrated screening is available to women who start prenatal care before the 14th week of pregnancy. Because this screening includes the NT ultrasound, you can get a preliminary result early in pregnancy. Final results are available soon after the second blood test. Click here for more details about sequential integrated screening.

SERUM INTEGRATED SCREENING
  • Two blood tests: One in the first trimester (10 to 13 weeks) and one in the second trimester (15 to 20 weeks)

Serum integrated screening is available to women who start prenatal care before the 14th week in pregnancy. Both blood tests can be done at your local Kaiser Permanente laboratory. Results are available soon after the second blood test. Click here for more information about serum integrated screening.

QUAD MARKER SCREENING
  • One blood test: The blood test is done between 15 weeks and 20 weeks.

Quad screening is offered to women who start prenatal care after 14 weeks and to women who start prenatal screening with NIPT.  Results are available one to two weeks after the blood draw. Click here for more information about Quad screening.

You can learn more about the California Prenatal Screening Program on their website:  Prenatal Screening Program

Last reviewed: March 11, 2021
Reviewed by: Kimberly Barr, MS, LCGC